Description
Product Characteristics:
Decorin is a member of the small, leucine rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF beta. It is believed that decorin also plays a role in the cell cycle of chondrocytes. Also known as: Decorin, Bone proteoglycan II, CSCD, DCN, DCN protein, Dermatan sulphate proteoglycans II, DKFZp686J19238, DSPG 2, DSPG2, PG 40, PG II, PG S2, PG40, PGII, PGS 2, PGS2, Proteoglycan core protein, SLRR1B, Small leucine rich protein 1B.
Subcellular location: Secreted, Extracellular matrix
Synonyms: CSCD, PG4, PGII, PGS2, DSPG2, SLRR1B, Decorin, Bone proteoglycan II, PG-S2, DCN
Target Information: The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]